The engine air filter element for the 3.5L V6 motor in a 3rd generation (2005, 2006, 2007, 2008, 2009 & 2010) Honda Odyssey minivan should be cleaned at every oil change and replaced at least every 2 to 3 years depending on your driving conditions. Check out my DIY instructions for the procedure (with the compatible replacement part numbers) by clicking on the text link or the thumbnail image below.